Dopaminergic axon guidance: which makes what?

Dopaminergic axon guidance: which makes what?

Mesotelencephalic pathways in the adult central nervous system have been studied in great detail because of their implication in major physiological functions as well as in psychiatric, neurological, and neurodegenerative diseases. However, the ontogeny of these pathways and the molecular mechanisms that guide dopaminergic axons during embryogenesis have been only recently studied. This line of...

Wnt5a Regulates Midbrain Dopaminergic Axon Growth and Guidance

During development, precise temporal and spatial gradients are responsible for guiding axons to their appropriate targets. Within the developing ventral midbrain (VM) the cues that guide dopaminergic (DA) axons to their forebrain targets remain to be fully elucidated. Wnts are morphogens that have been identified as axon guidance molecules. Several Wnts are expressed in the VM where they regula...

Axon guidance

The nervous system has the job of controlling and monitoring events throughout the whole body. But, unlike endocrine cells, which control their targets through long-range chemical cues, neurons communicate through direct cellular contacts, or synapses. As the information content of the electrical signals used by neurons is limited, much of the meaning in neural communication is conveyed by the ...

Polymeric Gas Separation Membranes: What Makes them Industrially more Attractive?

Diffusion in axon guidance.

Axon guidance by target-derived diffusible factors plays an important role in the development of the nervous system. This paper considers the constraints imposed on this process by the mathematics of diffusion. A point source continuously producing a factor into an infinite three-dimensional volume is considered as a model for both the in vivo and in vitro situation. Basic constraints for effec...